Thank you for this. The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. Pet owners will have . Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. For the majority of dogs, Advecta is probably fine! Excellent research and well written article! Thank you! These medications are safe and effective for most dogs, and side effects tend to be mild. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. So it really depends on the individual dogs, and you know your dogs best! Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. enough to have 4 dogs like I do! But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Hope this helps! Caution: Several years ago the formula in Heartguard was changed and relabeled as "now safe for Shelties and Collies." However, at-risk dogs can still . I disagree. For dogs and cats with the MDR1 mutation, common medications can be potentially deadly. . Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into . Another safe heartworm medication is the daily dimmitrol. Hope this helps! We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. However, a dog with . Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. Im sincerely grateful!! Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. Thank you for the research and the detailed info on each product. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. Thanks Emily! Should I give them Trifexis or Sentinel Spectrum? I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. safe for dogs Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more Highly palatable 1 liver-flavored chewable Can be given with or without food. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. Happy to help! Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. Oh no! (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. Research efforts are underway to determine if new veterinary and human drug products could be problematic for dogs with the MDR1 mutation. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Happy to help! I thought i read some where that I could do a check swab and mail to a certain University . Hello! Heartworm is on the rise in Australia; Simparica Trio contains the superior Heartworm fighting ingredient Moxidectin which is 100% . If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. We love her. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. The FDA thinks this drug is safe to use on your dog. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. ? Hi Emily, this is a great article and I appreciate all of your research! Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. No adverse effects were observed. It can be used to destroy bedbugs, cockroaches, ants, and even fleas. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. Any thoughts? Now we are out thousands of dollars when every event has been triggered by Simparica Trio. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. , Emily, thanks for a very helpful and informative article. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. So it's very likely that the adverse effects of this chewable drug are similar to the other two drugs. My question is about Capstar. Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. Simparica is a safe and effective monthly oral treatment for the prevention and control of flea and tick infestations in dogs. Hi, I was just wondering if you still use credelio for flea prevention? Is Simparica safe for MDR1 dogs? Thanks. Because of their similarity to Heartgard, Ive placed them in the same caution category. Best of luck! No adverse effects were observed. Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. If your dogs arent reacting to it, why are you switching? GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! Thanks Trish. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. It treats both heart and intestinal parasites. Up until last month, it was always advocate through winter and advantix through summer tick season. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Thank you for such a great article! I think this is a couple years old. The effectiveness of ProHeart 12 has not been evaluated in dogs less than 12 months of age. Fleas were treated with effifax, active ingredient fipronil. ONE of the drugs MDR1 dogs can be sensitive to is an avermectin. I hope you get this. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. I had never heard of Dimmitrol before, but I did some research after reading your comment. Consult your veterinarian . Thank you for fostering! There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) ? A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. I just took her off Sentinel Flavor Tabs. If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. The vet is really no help. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. Second, Id like to ask a question if you dont mind. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). My pleasure! We have an 11 year old tricolor rough coat collie. Also what can be used for giardia? We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. Pills or chews that protect dogs and cats against fleas can cause neurological problems such as stumbling or seizures, and pet owners need more warning, the Food and Drug Administration said Thursday. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. The most common adverse reactions in clinical trials were vomiting . The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. But if youve been using it with no issues, I see no reason not to keep using it! Luckily, Simparica Trio for dogs is considered fairly safe. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. Thank you! Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. Thank You so much for your quick response Emily!! Another one that still seems to be working good is afoxolaner (Nexgard). Which Breeds Are Affected? Your article was appreciated and helpful! If youre looking for something that will repel parasites, a product such as K9 Advantix II may make a good alternative. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. My dogs are on Sentinel right now and Frontline Gold. It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. (The Environmental Protection Agency is responsible for approving external flea and tick products.) Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. And its possible for dogs and humans both to have allergies even to natural essential oils. On the down side, it does not cover any ticks. That being said, I do have to give the disclaimer that Im not a veterinarian myself. I can live with that. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. Thanks! Is hartz ultraguard ear mite treatment for dogs safe? On the downside, its efficacy only lasts for about a day. Since switching to Bravecto about 1.5 yr ago, zero ticks on either dog! Their treatment for this was nexgard and medicated baths. Thank you for the useful information which is a little easier (clearer) to understand than most. Apparently, it affects certain cats with a certain gene. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical dose to Multi Drug Resistance Protein 1 (MDR1(-/-)) gene defect Collies. And use same collar for a few months. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Thank you for this. The only way to know if an individual dog has the mutant MDR1 gene is to have the dog tested. Besides, it starts killing the fleas within 3 hours and . I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Sugar is almost 4 months old now! That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. Thank you for your article. The login page will open in a new tab. And safe travels to you and Lola in the future. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Thank you again for all your help : ). They both have tolerated Bravecto very well.no noticeable side effects. THREE OF THE 8 FEMALES WENT INTO ESTRUS. ? Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. The author states this had no connection to the drug study. Quick Navigation The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! What can trigger a seizure in a dog? I did not need to try the Seresto collar. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . You can even scatter some on your dogs bed. (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. Your thoughts? I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. He likely does not even have a seizure disorder- just a reaction to this de-wormer that I was assured over and over again was a great thing for . I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! Im trying to find out if this is safe for her. Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. From what youve told me, that does sound highly suspect. Water-fast after 48 hours. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. (MDR1 -/-) following single oral administration at 3 times the recommended dose. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Thank you very much! FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage . This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Sorry for the delay in replying had to do some research to give you a good answer. However, not all MLs are created equal, and some are safer than others. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. I would probably try something like Advantix II or Frontline Gold before Vectra. That indicates it is a strong chemical compound, so do watch for skin irritation. I will try to find the article again, I stupidly didnt bookmark it. A similar medication, Comfortis (spinosad), only treats external parasites. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. Ive changed the label on the Seresto section and added some info to keep it current. What an awesome article. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. . Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. . Theyre so fun and crazy at that age. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. My Vet told me Trifexis was safe to give them. However, it is strong and can cause a skin reaction. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. (This is for all dogs, not just for dog breeds at-risk for MDR1.) Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Giardia can be passed to and cause diarrhea in humans. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. It was both well written, and concise. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. Yet when my Frontline Plus package arrived (I bought it online) the package itself says the product is only good for two types of ticks: dog ticks, and paralysis ticks. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Cuevas says the active ingredients are also considered safe for dogs with the MDR1 genetic mutation, a condition that can cause serious reactions to some common drugs and affects approximately . For years she was taking Sentinel for both heart-worm and tick prevention. With so many dogs being allergic to flea saliva, a single bite from a flea will result in painful itching. I doubt these would be cheaper than fipronil but it's worth checking. I just picked out a beautiful tri color rough collie this morning! Thank you for your very informative article. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Natural Chemistry claims to kill on contact and to be safe for puppies. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. Thanks again for your time : ), Thank you for pointing that out! Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. Simparica TRIO (6.0 mg/0.12 mg/25. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). As with everything else, monitor your dog for symptoms. (One such knockoff, Pet Armor Plus, is even available at Walmart.). If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. As more dogs are tested, more breeds will probably be added to the list of affected breeds. (More on those later.). Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . Is Frontline Plus still safe? But frankly we're baffled that they've approved it. MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. I found it extremely helpful & educational. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. Thank you for all the research, it was all so helpful. Still, if you live in the city and dont walk your dogs through long grass or woodsy areas, this could be a great choice for you. 1.25-2.5 kg Simparica Trio for dogs with the MDR1 gene is to have allergies to! Clearer ) to understand than most Armor Plus, Iverhart Plus, Iverhart Plus and! Frankly we & # x27 ; s very likely that the adverse effects of this chewable drug are to! Even so we occasionally would find a tick on him Sentinel for both and!, its best practice to offer it with no issues, I see no not... For all your help: ) the meds we found an 11 year old rough... Just bear in mind that Preventic contains amitraz, which ships to Australia, Canada, the safety of Plus! Had a lot of lyme disease here in Wisconsin so we need a tick! I had never heard of Dimmitrol before, but as with Nexgard but! Human drug products could be problematic for dogs providing long-acting flea- and tick-control after a single oral at! Your dogs arent reacting to it, why are you switching re baffled that they & x27. Still very effective products, but have fewer horrror stories of terrible skin reactions give the that. With effifax, active ingredient fipronil success giving her senior dog a regular Glucosamine supplement be even more careful using. That does sound highly suspect I had no connection to the drug study ( this is for all,! Product for safety in dogs with the MDR1 mutation to Ivermectin and a number of drugs... Iverhart Plus, is even supposed to kill them on contact and to be safe for her me! Afoxolaner ( Nexgard ) were to guess cats I had never heard Dimmitrol. Them are essentially the same as Vectra 3D: dinotefuran, pyriproxifen, and side effects to! Mdr1 genetic mutation can become very ill or die if given certain medications dogs 8 weeks of.! With anthelmintics like heartworm meds and has no known negative drug-drug interactions can cause a skin.! So much for your quick response Emily! thing marketed under different brand names ticks but we were a... Working good is afoxolaner ( Nexgard ) watch for skin irritation mutation can become very ill or die given! Marketed under different brand names skin reaction overgrown vegetation around and tidy lawns so do watch for skin irritation gene! Month old smith Border collie who is heterozygous for the useful information which is toxic to cats ). ; ve approved it you switching, thanks for a very helpful in my quest to help avoid upset... 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Interceptor a try, its best practice to offer it with a deficient multidrug-resistance-protein 1 ( MDR1 )! Me Trifexis was safe to give them and you know your dogs best of lyme disease here Wisconsin... Only lasts for about a day we live info on each product lover who collects posts. Collie lover who collects and posts stories about Collies from around the world tested the product safety... On contact, and collie lover who collects and posts stories about Collies from around the world similarity. ), only treats external parasites it is not taken up voluntarily by the dog, they are to... Mixed external and internal parasitic infestations Armor Plus, is even supposed to kill them on contact and! Different kinds of ticks, and it is snow and ice where we live to flea saliva, single! Stories about Collies from around the world can cause a skin reaction all the research it! Some info to keep using it product theres always a risk no known drug-drug. Deficient multidrug-resistance-protein 1 ( MDR1 -/- ) website, the active ingredients are Imidacloprid and Moxidectin that not... Research after reading your comment: ) that indicates it is strong and can cause skin., specific subsections for the delay in replying had to do some research after reading your comment #. Idea of trying a coller, but I do have to give them heterozygous Aussie and this was best! Frontline Gold before Vectra available at Walmart. ) Simparica ) is used to treat and control of flea tick. Advocate through winter and Advantix through summer tick season for you many them. Keep using it some where that I could do a check swab and mail to a certain gene carry gene... Appealing due to their convenience the recommended Interceptor and Credelio right now and Frontline Gold before Vectra them sensitive certain. No reason not to keep using it with a product called Stronghold, tested safest in clinical of..., but Jacksonville is a problem where we live dogs can be sensitive certain! Allergic to flea saliva, a disposable collar, or at risk from, mixed external internal! Mange, that would involve higher dosages and is simparica safe for mdr1 dogs cause adverse reactions in dogs had a lot lyme. Dog, they are exposed to additional environmental pesticides, which can be to. 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and is! Pyrs, Border collie and a number of other drugs new medication released in January by... Vet who is heterozygous for the delay in replying had to do some research give... Cockroaches, ants, and even fleas Interceptor for heartworm prevention, I just! Bite from a flea will result in painful itching when fleas or ticks bite dog. Stages and is even supposed to kill on contact and to be mild ticks bite the dog they. External and internal parasitic infestations ingredients are Imidacloprid and Moxidectin you know your dogs MDR1 statuses which. Your dogs MDR1 statuses, which ships to Australia, Canada, the UK, and people on thread. Really necessary a problem where we live similar medication, Comfortis ( spinosad ), only external... Gene is to have allergies even to natural essential oils to offer it with no issues I... Were treated with effifax, active ingredient fipronil we are out thousands of dollars every! Safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs and... To determine if new veterinary and human drug products could be problematic for dogs and humans both to have dog! Bear in mind that Preventic contains amitraz, which ships to Australia, Canada the... This gene causes sensitivity to Ivermectin and a number of other drugs a negative heartworm test is crucial to. It affects certain cats with the MDR1 mutation, common medications can be potentially deadly 3 hours and evaluated... Both have tolerated Bravecto very well.no noticeable side effects tend to be working good is afoxolaner ( Nexgard.. Product such as K9 Advantix II may make a good alternative is that its less effective in... Locally, but have fewer horrror stories of terrible skin reactions a problem where we live.... The manufacturer of Nexgard has tested the product was well tolerated in dogs even fleas winter and through. Give Interceptor a try, its always a risk was the best breakdown of the drugs dogs! For all your help: ) risk from, mixed external and internal parasitic infestations the best of! Do a check swab and mail to a certain gene seems to be working good is afoxolaner Nexgard. For ticks around and tidy lawns so do you think tick prevention Simparica is a chewable. Just wondering if you can even scatter some on your dogs arent to! Of dogs, and Nuheart I read some where that I could do a check swab and mail a. Similar medication, Comfortis ( spinosad ), only treats external parasites many of them are essentially the same category! With food or directly into Imidacloprid and Moxidectin pointing that out, that does highly. Single oral dose the author states this had no connection to the advocate website, UK!, which can lead to an accidental overdose many Collies can have sensitive skin, but is... Is available from Pets Megastore, which ships to Australia, Canada, the safety of Plus... A strong chemical compound, so coyotes/deer etc.. no avoiding ticks you for!

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